A wrapper to query DGIdb using R
نویسندگان
چکیده
Annotation and interpretation of DNA aberrations identified through next-generation sequencing is becoming an increasingly important task, especially in the context of data analysis pipelines for medical applications, where aberrations are associated with phenotypic and clinical features. A possible approach for annotation is to identify drugs as potential targets for aberrated genes or pathways. DGIdb accumulates data from 15 different gene-target interaction resources and allows querying these through their web interface as well as public API. rDGIdb is a wrapper to query DGIdb using R/Bioconductor. The package provides its output in a similar format as the web interface, and thereby allows integration of DGIdb queries into bioinformatic pipelines.
منابع مشابه
Genomic variant annotation workflow for clinical applications
Annotation and interpretation of DNA aberrations identified through next-generation sequencing is becoming an increasingly important task. Even more so in the context of data analysis pipelines for medical applications, where genomic aberrations are associated with phenotypic and clinical features. Here we describe a workflow to identify potential gene targets in aberrated genes or pathways and...
متن کاملDGIdb 2.0: mining clinically relevant drug-gene interactions
The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that consolidates disparate data sources describing drug-gene interactions and gene druggability. It provides an intuitive graphical user interface and a documented application programming interface (API) for querying these data. DGIdb was assembled through an extensive manual curation effort, reflecting the combined in...
متن کاملAn Effective Wrapper Architecture to Heterogeneous Data Source
In this paper, we focus on the problem in information integration system of obtaining data from heterogeneous data source accurately and effectively. XML is used as data exchange format of the wrapper. We design the wrapper architecture based on the conversion and management of the views as the bridge from global schema to local schema of various data sources. Our wrapper has two main subsystem...
متن کاملObject-Oriented Wrapper for Semistructured Data in a Data Grid Architecture
The paper addresses the problem of integrating data based on a XML-like semistructured model with a data grid architecture based on an object-oriented model. This work is continuation of the previous works on object-to-relational wrappers and covers a generic integration procedure for utilizing a native Lore query mechanism for retrieving data from XML data sources. A corresponding wrapper is f...
متن کاملA Meta - Wrapper for Scaling up to Multiple
Current mediator and wrapper architectures do not have the exibility to scale to multiple wrapped sources, where some sources may be redundant, and some sources may provide incomplete answers to a query. We propose a meta-wrapper component which is capable of handling multiple wrapped sources, in a particular domain, where the multiple sources provide related information. The meta-wrapper makes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016