A wrapper to query DGIdb using R

نویسندگان

  • Thomas Thurnherr
  • Franziska Singer
  • Daniel J. Stekhoven
  • Niko Beerenwinkel
چکیده

Annotation and interpretation of DNA aberrations identified through next-generation sequencing is becoming an increasingly important task, especially in the context of data analysis pipelines for medical applications, where aberrations are associated with phenotypic and clinical features. A possible approach for annotation is to identify drugs as potential targets for aberrated genes or pathways. DGIdb accumulates data from 15 different gene-target interaction resources and allows querying these through their web interface as well as public API. rDGIdb is a wrapper to query DGIdb using R/Bioconductor. The package provides its output in a similar format as the web interface, and thereby allows integration of DGIdb queries into bioinformatic pipelines.

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تاریخ انتشار 2016